Otezla
(Apremilast)

Prescription Settings Edit

Brand Name Choices

Otezla 30mg
Otezla 30mg

Manufactured by Celgene Corp

Product of United Kingdom

Dispensed by a licensed pharmacy in the United Kingdom

Prescription Required

Parallel Import

Generic Choices

No generic medication is available for Otezla (Apremilast)

What Otezla is and what it is used for

What Otezla is Otezla contains the active substance „apremilast‟. This belongs to a group of medicines called phosphodiesterase 4 inhibitors, which help to reduce inflammation. What Otezla is used for Otezla is used to treat adults with the following conditions:
• Psoriatic arthritis
•if you cannot use another type of medicine called „Disease-Modifying Antirheumatic Drugs‟ (DMARDs) or when you have tried one of these medicines and it did not work.
• Moderate to severe plaque psoriasis
•if you cannot use one of the following treatments or when you have tried one of these treatments and it did not work:
•phototherapy
•a treatment where certain areas of skin are exposed to ultraviolet light
•systemic therapy
•a treatment that affects the entire body rather than just one local area, such as „ciclosporin‟ or „methotrexate‟.What psoriatic arthritis is Psoriatic arthritis is an inflammatory disease of the joints, usually accompanied by psoriasis, an inflammatory disease of the skin. What plaque psoriasis is Psoriasis is an inflammatory disease of the skin, which can cause red, scaly, thick, itchy, painful patches on your skin and can also affect your scalp and nails. How Otezla works Psoriatic arthritis and psoriasis are usually lifelong conditions and there is currently no cure. Otezla works by reducing the activity of an enzyme in the body called „phosphodiesterase 4‟, which is involved in the process 2 of inflammation. By reducing the activity of this enzyme, Otezla can help to control the inflammation associated with psoriatic arthritis and psoriasis, and thereby reduce the signs and symptoms of these conditions. In psoriatic arthritis, treatment with Otezla results in an improvement in swollen and painful joints, and can improve your general physical function. In psoriasis, treatment with Otezla results in a reduction in psoriatic skin plaques and other signs and symptoms of the disease. Otezla has also been shown to improve the quality of life in patients with psoriasis or psoriatic arthritis. This means that the impact of your condition on daily activities, relationships and other factors should be less than it was before.

How to take Otezla

Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure. How much to take
• When you first start taking Otezla, you will receive a „treatment initiation pack‟ which contains all the doses as listed in the table below.
• The „treatment initiation pack‟ is clearly labelled to make sure you take the correct tablet at the correct time.
• Your treatment will start at a lower dose and will gradually be increased over the first 6 days of treatment.
• The „treatment initiation pack‟ will also contain enough tablets for another 8 days at the recommended dose (Days 7 to 14).
• The recommended dose of Otezla is 30 mg twice a day after the titration phase is complete
•one 30 mg dose in the morning and one 30 mg dose in the evening, approximately 12 hours apart, with or without food.
• This is a total daily dose of 60 mg. By the end of Day 6 you will have reached this recommended dose.
• Once the recommended dose has been reached, you will only get the 30 mg tablet strength in your prescribed packs. You will only ever need to go through this stage of gradually increasing your dose once even if you re-start treatment. People with kidney problems If you have severe kidney problems then the recommended dose of Otezla is 30 mg once a day (morning dose). Your doctor will talk to you about how to increase your dose when you first start taking Otezla How and when to take Otezla
• Swallow the tablets whole, preferably with water.
• You can take the tablets either with or without food.
• Take Otezla at about the same time each day, one tablet in the morning and one tablet in the evening.
• If your condition has not improved after six months of treatment, you should talk to your doctor. If you take more Otezla than you should If you take more Otezla than you should, talk to a doctor or go to a hospital straight away. Take the medicine pack and this leaflet with you. If you forget to take Otezla
• If you miss a dose of Otezla, take it as soon as you remember. If it is close to the time for your next dose, just skip the missed dose. Take the next dose at your regular time.
• Do not take a double dose to make up for a forgotten dose. If you stop taking Otezla
• You should continue taking Otezla until your doctor tells you to stop.
• Do not stop taking Otezla without talking to your doctor first. If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. Some side effects could be serious.

Uncommon instances of suicidal thinking and behaviour (including suicide) were reported. Please notify your doctor immediately of any feelings of depression, suicidal thoughts or suicidal behaviour you may have. You may also experience sleeplessness (common), or depressive mood (common).

Very common side effects (may affect more than 1 in 10 people)
• diarrhoea
• nausea

Common side effects (may affect up to 1 in 10 people)
• cough
• back pain
• vomiting
• feeling tired
• stomach pain
• loss of appetite
• frequent bowel movements
• difficulty sleeping (insomnia)
• indigestion or heartburn
• headaches, migraines or tension headaches
• upper respiratory tract infections such as cold, runny nose, sinus infection
• inflammation and swelling of the tubes in your lungs (bronchitis)
• common cold (nasopharyngitis)
• depression 5

Uncommon side effects (may affect up to 1 in 100 people)
• rash
• weight loss
• allergic reaction
• bleeding in the bowel or in the stomach
• suicidal ideation or behaviour If you are 65 years of age or older, you might have higher risk of complications of severe diarrhea, nausea and vomiting. If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.

Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme, Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.

How to Store Otezla

Keep this medicine out of the sight and reach of children.
• Do not use this medicine after the expiry date which is stated on the blister and carton after EXP. The expiry date refers to the last day of that month.
• Do not store above 30°C.
• Do not use this medicine if you notice any damage or signs of tampering to the medicine packaging. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

Fast Shipping

2 to 3 weeks on average

The average shipping time is 2 to 3 weeks in North America and 4 to 6 weeks internationally. We offer free shipping on all orders shipped to North America. Shipping is a flat rate of $20.00 for all other countries.

Price Match Guarantee

If you have been prescribed medication by your doctor and cannot afford the high price at your local pharmacy, Medix Pharmacy is the solution for you. All orders are backed with a price match and satisfaction guarantee.

About Medix Pharmacy

Medix Pharmacy is a fully licensed pharmacy in the United Kingdom who provides competitive pricing on brand and generic medications with international shipping.

We are regulated by a number of executive government agencies in the United Kingdom including the Medicines and Healthcare products Regulatory Agency and the GPhC to ensure we offer our customers the highest level of service and peace of mind knowing that the medicines that you receive are safe, effective and authentic.

Drug prices for Otezla vary throughout the world with the highest prices generally in the United States. Patients can save significantly on their prescriptions drugs when purchasing them from a licensed pharmacy in the United Kingdom and other countries such as Canada, Australia, and New Zealand.

If you are unable to find your prescribed medicine on our website, please fill out the form below and we will confirm pricing and availability within 1 business day. You may also call us at 1-866-500-6633 and one of our patient care representatives will be happy to assist you.