Brand Name Choices
No generic medication is available for Daliresp (Roflumilast)
What Daliresp is and what it is used for
Daxas contains the active substance roflumilast, which is an anti-inflammatory medicine called phosphodiesterase-4 inhibitor. Roflumilast reduces the activity of phosphodiesterase-4, a protein occurring naturally in body cells. When the activity of this protein is reduced, there is less inflammation in the lungs. This helps to stop narrowing of airways occurring in chronic obstructive pulmonary disease (COPD). Thus Daxas eases breathing problems. Daxas is used for maintenance treatment of severe COPD in adults who in the past had frequent worsening of their COPD symptoms (so-called exacerbations) and who have chronic bronchitis. COPD is a chronic disease of the lungs that results in tightening of the airways (obstruction) and swelling and irritation of the walls of the small air passages (inflammation). This leads to symptoms such as coughing, wheezing, chest tightness or difficulty in breathing. Daxas is to be used in addition to bronchodilators.
How to take Daliresp
Always take this medicine exactly as your doctor has told you. Check with your doctor or
pharmacist if you are not sure.
• For the first 28 days
•the recommended starting dose is one 250 micrograms tablet once daily.
•The starting dose is a low dose used to help your body get used to the medicine before you start taking the full dose. At this low dose you will not get the full effect from the medicine – therefore it is important that you move on to the full dose (called a ‘maintenance dose’) after 28 days.
• After 28 days
•the recommended maintenance dose is one 500 micrograms tablet once daily. Swallow the tablet with some water. You may take this medicine with or without food. Take the tablet at the same time every day. You may need to take Daxas for several weeks to achieve its beneficial effect. If you take more Daxas than you should If you have taken more tablets than you should, you may experience the following symptoms: headache, nausea, diarrhoea, dizziness, throbbing of your heart, light-headedness, clamminess and low blood pressure. Tell your doctor or pharmacist straight away. If possible take your medicine and this leaflet with you. If you forget to take Daxas If you forget to take a tablet at the usual time, take the tablet as soon as you remember on the same day. If on one day you have forgotten to take a tablet of Daxas, just carry on the next day with the next tablet as usual. Continue taking your medicine at the usual times. Do not take a double dose to make up for a forgotten dose. 4 If you stop taking Daxas It is important to continue taking Daxas for as long as prescribed by your doctor, even when you have no symptoms, in order to maintain control of your lung function. If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
You may experience diarrhoea, nausea, stomach ache or headache during the first weeks of
treatment with Daxas. Talk to your doctor if these side effects do not resolve within the first
weeks of treatment.
Some side effects could be serious. In clinical studies and post-marketing experience, rare
instances of suicidal thinking and behaviour (including suicide) were reported. Please notify
your doctor immediately of any suicidal thoughts you may have. You may also experience
sleeplessness (common), anxiety (uncommon), nervousness (rare), panic attack (rare) or
depressive mood (rare).
In uncommon cases allergic reactions may occur. Allergic reactions may affect the skin and in
rare cases cause swelling of the eyelids, face, lips and tongue, possibly leading to difficulties
in breathing and/or a drop in blood pressure and accelerated heartbeat. In case of an allergic
reaction, stop taking Daxas and contact your doctor immediately, or go immediately to the
emergency department in the nearest hospital. Take all your medicines and this leaflet with
you and provide full information of your current medications.
Other side effects include the following:
Common side effects (may affect up to 1 in 10 people)
•diarrhoea, nausea, stomach ache
•weight decrease, decreased appetite
Uncommon side effects (may affect up to 1 in 100 people)
•trembling, sensation of spinning head (vertigo), dizziness
•sensation of rapid or irregular heartbeat (palpitations)
•reflux of stomach acid to the gullet (acid regurgitations), indigestion
•muscle pain, muscle weakness or cramps
•feeling of weakness or tiredness, feeling unwell.
Rare side effects (may affect up to 1 in 1,000 people)
•male breast enlargement
•decreased sense of taste
•respiratory tract infections (excluding pneumonia)
•bloody stools, constipation
•elevation of liver or muscle enzymes (seen in blood tests) 5
Reporting of side effects If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly (see details below). By reporting side effects you can help provide more information on the safety of this medicine. United Kingdom Yellow Card Scheme Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. Ireland HPRA Pharmacovigilance Earlsfort Terrace IRL
•Dublin 2 Tel: +353 1 6764971 Fax: +353 1 6762517 Website: www.hpra.ie e-mail: [email protected] Malta ADR Reporting Website: www.medicinesauthority.gov.mt/adrportal
How to Store Daliresp
Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date which is stated on the carton and blister after EXP. The expiry date refers to the last day of that month. This medicine does not require any special storage conditions. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
2 to 3 weeks on average
The average shipping time is 2 weeks in North America and 4 weeks internationally. We offer free shipping on all orders shipped to North America. Shipping is a flat rate of $20.00 for all other countries.
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About Medix Pharmacy
Medix Pharmacy is a fully licensed pharmacy in the United Kingdom who provides competitive pricing on brand and generic medications with international shipping.
We are regulated by a number of executive government agencies in the United Kingdom including the Medicines and Healthcare products Regulatory Agency and the GPhC to ensure we offer our customers the highest level of service and peace of mind knowing that the medicines that you receive are safe, effective and authentic.
Drug prices for Daliresp vary throughout the world with the highest prices generally in the United States. Patients can save significantly on their prescriptions drugs when purchasing them from a licensed pharmacy in the United Kingdom and other countries such as Canada, Australia, and New Zealand.